The space shuttle, during its re-entry and landing phase, typically descended from orbit at a speed of approximately 28,000 kilometers per hour (17,500 miles per hour). As it entered Earth's atmosphere, the shuttle gradually decelerated due to atmospheric drag and its own control systems. By the time it touched down on the runway, its speed was significantly reduced to around 350 kilometers per hour (220 miles per hour) or even slower, depending on various factors such as the landing site and specific mission requirements.
It's important to note that the specific landing speed could vary between different missions and circumstances, but the figures provided above give a general idea of the speeds involved during the shuttle's landing phase.