The recommended internal temperature for cooked meatloaf, as with other ground meats, is 160°F (71°C) according to food safety guidelines. It's essential to ensure that the meatloaf reaches this temperature to ensure it is cooked thoroughly and safe to eat. Using a meat thermometer is the most accurate way to determine the internal temperature of the meatloaf. Insert the thermometer probe into the thickest part of the meatloaf, avoiding contact with the pan or any bone if the meatloaf contains them. When the thermometer reads 160°F (71°C), the meatloaf is considered done and safe to consume.